Porphyromonas gingivalis-specific immunoglobulin G prevents P-gingivalis-elicited oral bone loss in a murine model

被引：24

作者：

Gibson, FC

Gonzalez, DA

Wong, J

Genco, CA

机构：

[1] Boston Univ, Med Ctr, Dept Med, Infect Dis Sect, Boston, MA 02118 USA

[2] Boston Univ, Med Ctr, Goldman Sch Dent Med, Dept Oral Biol & Periodontol, Boston, MA 02118 USA

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 04期

关键词：

D O I：

10.1128/IAI.72.4.2408-2411.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Active immunization with Porphyromonas gingivalis whole-cell preparations has been shown to prevent P. gingivalis infection and oral bone loss. Employing passive antibody transfer and opsonization, we demonstrate with this study that immunization-elicited P. gingivalis-specific immunoglobulin G facilitates clearance of P. gingivalis in a subcutaneous chamber model and prevents P. gingivalis-elicited oral bone loss.

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页码：2408 / 2411

页数：4

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