Giant cell angiofibroma of the orbit and eyelid

Purpose: To report the clinicopathologic features of a newly recognized tumor, giant cell angiofibroma, Design: Observational case series. Main Outcome Measures: Clinical and histopathologic features of giant cell angiofibroma; Methods: Light and electron microscopy and immunohistochemistry of five cases of giant cell angiofibroma, Results: A total of five patients (4 women and 1 man) are described: two presented with a painless mass in the eyelid, two with a mass in the orbit, and one presented with a conjunctival lesion. All lesions were well demarcated with no capsule and were composed of blood vessels, a patternless spindle-shaped cell proliferation with a solid and pseudovascular appearance, and multinucleated giant cells. Both spindle-shaped and giant tumor cells were intensely positive for CD34 and vimentin, Conclusion: Giant cell angiofibroma resembles solitary fibrous tumor and giant cell fibroblastoma and should;be considered in the differential diagnosis of spindle-cell tumors in the eyelid, orbit, and conjunctiva.