Microglia: Scapegoat, Saboteur, or Something Else?

被引：667

作者：

Aguzzi, Adriano ^{[1
]}

Barres, Ben A. ^{[2
]}

Bennett, Mariko L. ^{[2
]}

机构：

[1] Univ Zurich Hosp, Inst Neuropathol, CH-8012 Zurich, Switzerland

[2] Stanford Univ, Sch Med, Dept Neurobiol, Stanford, CA 94305 USA

来源：

SCIENCE | 2013年 / 339卷 / 6116期

基金：

欧洲研究理事会;

关键词：

CENTRAL-NERVOUS-SYSTEM; BETA-AMYLOID PLAQUES; ALZHEIMERS-DISEASE; AXON REGENERATION; APOPTOTIC BODIES; MYELOID CELLS; MOUSE MODEL; BRAIN; COMPLEMENT; ACTIVATION;

D O I：

10.1126/science.1227901

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Microglia are resident immune cells in the brain and spinal cord. These cells provide immune surveillance and are mobilized in response to disparate diseases and injuries. Although microglial activation is often considered neurotoxic, microglia are essential defenders against many neurodegenerative diseases. It also seems increasingly likely that microglial dysfunction can underlie certain neurological diseases without an obvious immune component.

引用

页码：156 / 161

页数：6

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