Genetic diversity of mumps virus in oral fluid specimens: Application to mumps epidemiological study

被引:41
作者
Jin, L
Brown, DWG
Litton, PA
White, JM
机构
[1] Hlth Protect Agcy, Enter Resp & Neurol Virus Lab, London NW9 5HT, England
[2] Hlth Protect Agcy, Immunisat Div, Ctr Communicable Dis Surveillance, London NW9 5HT, England
关键词
D O I
10.1086/382134
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Three hundred nine mumps virus (MuV) strains detected in the United Kingdom during 1995-2002 were characterized by partial sequencing of the small hydrophobic gene and were shown to belong to at least 6 different genotypes. A strain representing a new genotype was isolated from a seminal fluid specimen. Identical strains belonging to genotypes G and C were found to circulate for up to 3 years. One genotype H strain reappeared after an absence of 4 years. Distinct lineages (G1-G7) within genotype G were recognizable in the present study, and this level of characterization proved to be very useful for tracking MuV importations and subsequent transmission. We propose, here, a preliminary standardization of international nomenclature for genetic characterization of MuV strains, to facilitate future molecular epidemiological studies of mumps. Oral fluid (OF) specimens (n = 1441) were used to detect both anti-MuV IgM and MuV genome, and the results indicate that OF specimens can be used successfully for diagnosis and have the potential to play a valuable role in diagnosis and surveillance of mumps.
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收藏
页码:1001 / 1008
页数:8
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