Properly designed modular asymmetric synthesis for enantiopure sulfinamide auxiliaries from N-sulfonyl-1,2,3-oxathiazolidine-2-oxide agents

被引：102

作者：

Han, ZX ^{[1
]}

Krishnamurthy, D ^{[1
]}

Grover, P ^{[1
]}

Fang, QK ^{[1
]}

Senanayake, CH ^{[1
]}

机构：

[1] Sepracor Inc, Chem Proc Res & Dev, Marlborough, MA 01752 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 27期

关键词：

D O I：

10.1021/ja0200692

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Simple and practical asymmetric synthesis of functionally differentiated aminoindanol based endo-N-sulfonyl 1,2,3-oxathiazolidine-2-oxide as sulfinyl transfer agents are developed. The importance of these new and unique sulfinyl transfer reagents are exemplified by the expedient production of several sulfinamide ligands, including either enantiomer of (R)-tert-butanesulfinamide in excellent yields and enantiopurities. Copyright © 2002 American Chemical Society.

引用

页码：7880 / 7881

页数：2

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