Use of fluoroquinolones as prophylactic agents in patients with neutropenia

被引:20
作者
Patrick, CC [1 ]
机构
[1] UNIV TENNESSEE, COLL MED, DEPT PEDIAT, MEMPHIS, TN USA
关键词
fluoroquinolones; selective decontamination; neutropenia; bacterial infections;
D O I
10.1097/00006454-199701000-00038
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. The use of fluorinated quinolone antibiotics to selectively decontaminate the gastrointestinal tract is a reasonable alternative to prevent infection in neutropenic patients. The fluoroquinolones represent ideal antibiotics with which to achieve the principles of selective decontamination by allowing colonization of anaerobes to inhibit the adherence, colonization and proliferation of potentially pathogenic aerobic flora. Objective. This report describes the prophylactic use of fluoroquinolones in neutropenic patients. Results. The majority of studies of fluoroquinolone prophylaxis in neutropenic patients have shown a reduction in documented Gram-negative bacterial infections. However, Gram-positive infections, particularly those with viridans streptococci, present a major impediment to the use of single agent prophylaxis with a quinolone. Conclusion. Prophylaxis with fluoroquinolones in neutropenic patients was found to be advantageous, but it must be balanced against the risk of Gram-positive infections and the potential for antibiotic resistance.
引用
收藏
页码:135 / 139
页数:5
相关论文
共 40 条
[1]   BACTEREMIA DUE TO VIRIDANS STREPTOCOCCUS IN NEUTROPENIC PATIENTS WITH CANCER - CLINICAL SPECTRUM AND RISK-FACTORS [J].
BOCHUD, PY ;
EGGIMAN, P ;
CALANDRA, T ;
VANMELLE, G ;
SAGHAFI, L ;
FRANCIOLI, P .
CLINICAL INFECTIOUS DISEASES, 1994, 18 (01) :25-31
[2]   QUANTITATIVE RELATIONSHIPS BETWEEN CIRCULATING LEUKOCYTES AND INFECTION IN PATIENTS WITH ACUTE LEUKEMIA [J].
BODEY, GP ;
BUCKLEY, M ;
SATHE, YS ;
FREIREICH, EJ .
ANNALS OF INTERNAL MEDICINE, 1966, 64 (02) :328-+
[3]   COMPARISON OF NORFLOXACIN WITH COTRIMOXAZOLE FOR INFECTION PROPHYLAXIS IN ACUTE-LEUKEMIA - THE TRADE-OFF FOR REDUCED GRAM-NEGATIVE SEPSIS [J].
BOW, EJ ;
RAYNER, E ;
LOUIE, TJ .
AMERICAN JOURNAL OF MEDICINE, 1988, 84 (05) :847-854
[4]  
CHYSKY V, 1991, INFECTION, V19, P3
[5]  
CLASENER HAL, 1987, REV INFECT DIS, V9, P295
[6]   PROPHYLACTIC CO-TRIMOXAZOLE VERSUS NORFLOXACIN IN NEUTROPENIC CHILDREN - PERSPECTIVE RANDOMIZED STUDY [J].
CRUCIANI, M ;
CONCIA, E ;
NAVARRA, A ;
PERVERSI, L ;
BONETTI, F ;
ARICO, M ;
NESPOLI, L .
INFECTION, 1989, 17 (02) :65-69
[7]   PHARMACOKINETICS AND TISSUE PENETRATION OF CIPROFLOXACIN [J].
CRUMP, B ;
WISE, R ;
DENT, J .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1983, 24 (05) :784-786
[8]  
Dekker A W, 1990, Haematol Blood Transfus, V33, P551
[9]   INFECTION PROPHYLAXIS IN ACUTE-LEUKEMIA - A COMPARISON OF CIPROFLOXACIN WITH TRIMETHOPRIM-SULFAMETHOXAZOLE AND COLISTIN [J].
DEKKER, AW ;
ROZENBERGARSKA, M ;
VERHOEF, J .
ANNALS OF INTERNAL MEDICINE, 1987, 106 (01) :7-12
[10]   PREVENTION OF BACTERIAL-INFECTION IN NEUTROPENIC PATIENTS WITH HEMATOLOGIC MALIGNANCIES - A RANDOMIZED, MULTICENTER TRIAL COMPARING NORFLOXACIN WITH CIPROFLOXACIN [J].
DELFAVERO, A .
ANNALS OF INTERNAL MEDICINE, 1991, 115 (01) :7-12