Preparation, characterization and biological studies of some novel ferrocenyl compounds

被引：16

作者：

Abd-Elzaher, MM

Ali, IAI

机构：

[1] Natl Res Ctr, Dept Inorgan Chem, Cairo, Egypt

[2] Suez Canal Univ, Fac Sci, Dept Chem, Ismailia, Egypt

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2006年 / 20卷 / 02期

关键词：

ferrocene; trichloroacetimidates; ferrocenyl carbohydrates; characterization; biological activity;

D O I：

10.1002/aoc.1016

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Reaction of ferrocene with trichloroacetimidates in the presence of TMSOTf as a catalyst gave a series of novel ferrocenyl compounds, 1-7, in good yield and by a simple method using the Friedel-Crafts reaction. Only monosubstituted ferrocenyl compounds were obtained by flash chromatography at room temperature. Attempts to separate the disubstituted ferrocenyl compounds were unsuccessful, even in the presence of excess (2:1,3: 1 or 4: 1) of trichloroacetimidates. The prepared compounds have been characterized by H-1 NMR, C-13 NMR, IR, UV-vis and mass spectra as well as elemental analysis. The prepared compounds showed medium to good antimicrobial activity against Bacillus subtilis (+ve), Staphylococcus aureus (+ve), Candida albicans (yeast), Escherichia coli (-ve), Salmonella typhi (-ve), Aspergillus niger (fungi) and Fusarium solani (fungi). Copyright (c) 2005 John Wiley & Sons, Ltd.

引用

页码：107 / 111

页数：5

共 44 条

[1] Synthesis, characterization and biological studies of ferrocenyl complexes containing thiophene moiety [J].