Asian scorpion BmK venom induces plasma extravasation and thermal hyperalgesia in the rat

被引:27
作者
Chen, B [1 ]
Zhuo, XP [1 ]
Wang, CY [1 ]
Ji, YH [1 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Physiol, Shanghai 200031, Peoples R China
基金
中国国家自然科学基金;
关键词
scorpion Buthus martensi Karsch venom; plasma extravasion; peripheral inflammation; morphine; paw withdrawal latency; thermal hyperalgesia;
D O I
10.1016/S0041-0101(01)00248-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In the present study, the effects of scorpion Buthus martensi Karsch (BmK) venom on plasma extravasation and paw withdrawal latency (PWL) to radiant heat have been investigated in rats. BmK venom (20-200 mug/kg) by subcutaneous injection under the surface of the rat hindpaw causes dose-dependant increased plasma extravasation that could be partially inhibited by intraperitoneal (i.p.) injected morphine (6 mg/kg). Peak plasma extravasation was reached at 10 min and persisted for 60 min at a dose of 200 mug/kg, BmK venom induced cutaneous hyperalgesia as indicated by decreased PWL to radiant heat in the ipsilateral paw following subcutaneous injection of 20 mug/kg BmK venom without effect on PWL of the contralateral hindpaw. Meanwhile, it was found that i.p. morphine injection could inhibit this decreased ipsilateral PWL. The results thus suggest that BmK venom could induce peripheral inflammation in rat by subcutaneous injection, and may prove a valuable animal model for investigating the pathophysiology of a number of inflammatory diseases and identifying potential anti-inflammatory and analgesic drugs. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:527 / 533
页数:7
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