Origin of genes

被引：198

作者：

Gilbert, W

deSouza, SJ

Long, MY

机构：

[1] Dept. of Molec. and Cellular Biology, Biological Laboratories, Harvard University, Cambridge, MA 02138

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 15期

关键词：

intron; exon; module; evolution;

D O I：

10.1073/pnas.94.15.7698

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We discuss two tests of the hypothesis that the first genes crc re assembled from exons, The hypothesis of exon shuffling in the progenote predicts that intron phases will be correlated so that exons will be an integer number of codons and predicts that the exons will he correlated with compact regions of polypeptide chain, These predictions have been tested on ancient conserved proteins (proteins without introns in prokaryotes hut with introns in eukaryotes) and hold with high statistical significance. We conclude that introns are correlated with computer features of proteins 15-, 22-, or 30-amino acid residues long, as was predicted by ''The Exon Theory of Genes.''

引用

页码：7698 / 7703

页数：6

共 17 条

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