A direct, one step synthesis of imidazoles from imines and acid chlorides: A palladium catalyzed multicomponent coupling approach

被引：132

作者：

Siamaki, Ali R. ^{[1
]}

Arndtsen, Bruce A. ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 18期

关键词：

D O I：

10.1021/ja060705m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed one-step synthesis of imidazoles from imines and acid chlorides is described. A plausible mechanism for this multicomponent reaction is provided, which explains the selective incorporation of two different imines into the final product with perfect regiocontrol. Overall, this catalytic process provides a modular method to prepare imidazoles directly from building blocks that are all either commercially available or readily generated. Copyright © 2006 American Chemical Society.

引用

页码：6050 / 6051

页数：2

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