Make mouse studies work

被引：440

作者：

Perrin, Steve ^{[1
]}

机构：

[1] ALS Therapy Dev Inst, Cambridge, MA USA

来源：

NATURE | 2014年 / 507卷 / 7493期

关键词：

AMYOTROPHIC-LATERAL-SCLEROSIS; LITHIUM; ALS; TRIAL; MICE; PROGRESSION; TDP-43; MODEL;

D O I：

10.1038/507423a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

More investment to characterize animal models can boost the ability of preclinical work to predict drug effects in humans, says Steve Perrin.

引用

页码：423 / 425

页数：3

共 13 条

[1] Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial [J].

Aggarwal, Swati P. ;

Zinman, Lorne ;

Simpson, Elizabeth ;

McKinley, Jane ;

Jackson, Katherine E. ;

Pinto, Hanika ;

Kaufman, Petra ;

Conwit, Robin A. ;

Schoenfeld, David ;

Shefner, Jeremy ;

Cudkowicz, Merit .

LANCET NEUROLOGY, 2010, 9 (05) :481-488

[2]

Allen C, 2013, LANCET NEUROL, V12, P339, DOI [10.1016/S1474-4422(13)70037-1, 10.1016/S1474-4422(13)700374]

[3] Raise standards for preclinical cancer research [J].

Begley, C. Glenn ;

Ellis, Lee M. .

NATURE, 2012, 483 (7391) :531-533

[4] Lithium delays progression of amyotrophic lateral sclerosis [J].

Fornai, Francesco ;

Longone, Patrizia ;

Cafaro, Luisa ;

Kastsiuchenka, Olga ;

Ferrucci, Michela ;

Manca, Maria Laura ;

Lazzeri, Gloria ;

Spalloni, Alicia ;

Bellio, Natascia ;

Lenzi, Paola ;

Modugno, Nicola ;

Siciliano, Gabriele ;

Isicloro, Ciro ;

Murri, Luigi ;

Ruggieri, Stefano ;

Paparelli, Antonio .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (06) :2052-2057

[5] No Benefit from Chronic Lithium Dosing in a Sibling-Matched, Gender Balanced, Investigator-Blinded Trial Using a Standard Mouse Model of Familial ALS [J].

Gill, Alan ;

Kidd, Joshua ;

Vieira, Fernando ;

Thompson, Kenneth ;

Perrin, Steven .

PLOS ONE, 2009, 4 (08)

[6]

Hatzipetros T., 2013, BRAIN RES

[7] Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis [J].

Ling, Shuo-Chien ;

Polymenidou, Magdalini ;

Cleveland, Don W. .

NEURON, 2013, 79 (03) :416-438

[8] Guidelines for preclinical animal research in ALS/MND: A consensus meeting [J].

Ludolph, Albert C. ;

Bendotti, Caterina ;

Blaugrund, Eran ;

Chio, Adriano ;

Greensmith, Linda ;

Loeffler, Jean-Philippe ;

Mead, Richard ;

Niessen, Heiko G. ;

Petri, Susanne ;

Pradat, Pierre-Francois ;

Robberecht, Wim ;

Ruegg, Markus ;

Schwalenstoecker, Birgit ;

Stiller, Detlev ;

van den Berg, Leonard ;

Vieira, Fernando ;

von Horsten, Stephan .

AMYOTROPHIC LATERAL SCLEROSIS, 2010, 11 (1-2) :38-45

[9] Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice [J].

Pizzasegola, Chiara ;

Caron, Ilaria ;

Daleno, Cristina ;

Ronchi, Anna ;

Minoia, Claudio ;

Carri, Maria Teresa ;

Bendotti, Caterina .

AMYOTROPHIC LATERAL SCLEROSIS, 2009, 10 (04) :221-228

[10] Design, power, and interpretation of studies in the standard murine model of ALS [J].

Scott, Sean ;

Kranz, Janice E. ;

Cole, Jeff ;

Lincecum, John M. ;

Thompson, Kenneth ;

Kelly, Nancy ;

Bostrom, Alan ;

Theodoss, Jill ;

Al-Nakhala, Bashar M. ;

Vieira, Fernando G. ;

Ramasubbu, Jeyanthi ;

Heywood, James A. .

AMYOTROPHIC LATERAL SCLEROSIS, 2008, 9 (01) :4-15

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