Antiplatelet actions of aporphinoids from formosan plants

被引：26

作者：

Chia, YC

Chen, KS

Chang, YL

Teng, CM

Wu, YC ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Tajen Inst Technol, Ping Tung Hsien 907, Taiwan

[3] Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei 100, Taiwan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 23期

关键词：

alkaloids; anticoagulants; natural products; plants;

D O I：

10.1016/S0960-894X(99)00593-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seventeen aporphines were tested for antiplatelet activity. L-(+)-hernovine HCl and 7-hydroxydehydrothalicsimidine strongly inhibited platelet aggregation induced by adenosine 5'-diphosphate (ADP), arachidonic acid (AA), collagen, and platelet-activating factor (PAF). The latter showed the strongest antiplatelet activity with an IC50 of 70.4 mu M against AA-induced platelet aggregation. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3295 / 3300

页数：6

共 18 条

[1] Two new 7-dehydroaporphine alkaloids and antiplatelet action aporphines from the leaves of Annona purpurea
Chang, FR
Wei, JL
Teng, CM
Wu, YC
[J]. PHYTOCHEMISTRY, 1998, 49 (07) : 2015 - 2018
[2] Antiplatelet aggregation constituents from Annona purpurea
Chang, FR
Wei, JL
Teng, CM
Wu, YC
[J]. JOURNAL OF NATURAL PRODUCTS, 1998, 61 (12): : 1457 - 1461
[3] Bioactive alkaloids from Illigera luzonensis
Chen, KS
Wu, YC
Teng, CM
Ko, FN
Wu, TS
[J]. JOURNAL OF NATURAL PRODUCTS, 1997, 60 (06): : 645 - 647
[4] Antiplatelet and vasorelaxing actions of some aporphinoids
Chen, KS
Ko, FN
Teng, CM
Wu, YC
[J]. PLANTA MEDICA, 1996, 62 (02) : 133 - 136
[5] VASORELAXING EFFECT IN RAT THORACIC AORTA CAUSED BY LAUROTETANINE ISOLATED FROM LITSEA-CUBEBA PERSOON
CHEN, WY
KO, FN
WU, YC
LU, ST
TENG, CM
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1994, 46 (05) : 380 - 382
[6] (-)-DISCRETAMINE, A SELECTIVE ALPHA(1D)-ADRENOCEPTOR ANTAGONIST, ISOLATED FROM FISSISTIGMA-GLAUCESCENS
KO, FN
GUH, JH
YU, SM
HOU, YS
WU, YC
TENG, CM
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1994, 112 (04) : 1174 - 1180
[7] PROAPORPHINE-APORPHINE DIMERS AND A BIS-APORPHINE DERIVED FROM TUMOR-INHIBITORY ALKALOID THALICARPINE
KUPCHAN, SM
DHINGRA, OP
RAMACHANDRAN, V
KIM, CK
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1978, 43 (01) : 105 - 108
[8] STUDIES ON ALKALOIDS OF FORMOSAN LAURACEOUS PLANTS .18. ALKALOIDS OF NEOLITSEA-BUISANENSIS YAMAMOTO ET KAMIKOTI AND NEOLITSEA-AURATA (HAY) KOIDZ
LU, ST
SU, TL
WANG, EC
[J]. JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 1975, 22 (04) : 349 - 353
[9] STUDIES ON ALKALOIDS OF FORMOSAN LAURACEOUS PLANTS .15. ALKALOIDS OF LINDERA-OLDHAMII HEMSL
LU, ST
LIN, LC
LIN, CM
WANG, SJ
LAI, PH
[J]. YAKUGAKU ZASSHI, 1972, 92 (07): : 910 - &
[10] STUDIES ON ALKALOIDS OF FORMOSAN LAURACEOUS PLANTS .16. ALKALOIDS OF NEOLITSEA-VARIABILLIMA (HAY) KANEHIRA ET SASAKI
LU, ST
SU, TL
[J]. JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 1973, 20 (02) : 75 - 81

← 1 2 →