Upregulation of leptin receptor mRNA expression in obese mouse brain

被引：42

作者：

Huang, XF ^{[1
]}

Lin, S ^{[1
]}

Zhang, R ^{[1
]}

机构：

[1] UNIV WOLLONGONG,DEPT BIOL,WOLLONGONG,NSW 2522,AUSTRALIA

来源：

NEUROREPORT | 1997年 / 8卷 / 04期

关键词：

C57B1/6; mice; gene; hypothalamus; metabolism; obesity;

D O I：

10.1097/00001756-199703030-00043

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

LEPTIN receptor gene expression in the brains of lean (+/+) and obese (ob/ob) C57Bl/6 mice was examined using a non-radioactive in situ hybridization detection method. Significant increases in leptin receptor mRNA expression were found in the ventromedial and arcuate hypothalamic nuclei, piriform and olfactory cortices and medial habenular nucleus. There changes in the amount expression in hippocampus proper (CA1-3). Results indicated that leptin receptor is upregulated when there is a lack of functional leptin, as in hereditary obese (ob/ob) mice. It is also suggested that leptin receptor may be an autoreceptor.

引用

页码：1035 / 1038

页数：4

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