Basal and Postprandial Serum Levels of Gastrin in Normotensive and Hypertensive Adults

被引：27

作者：

Jiang, Xiaoliang ^{[1
,2
]}

Wang, Wenjie ^{[1
,2
]}

Ning, Bin ^{[3
]}

Liu, Xing ^{[1
,2
]}

Gong, Jian ^{[3
]}

Gan, Fusheng ^{[3
]}

Gao, Xuezhong ^{[3
]}

Zhang, Lianfeng ^{[1
,2
]}

Jose, Pedro A. ^{[4
]}

Qin, Chuan ^{[1
,2
]}

Yang, Zhiwei ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Minist Hlth, Inst Lab Anim Sci, Key Lab Human Dis Comparat Med, Beijing 100021, Peoples R China

[2] Peking Union Med Coll, Comparat Med Ctr, Beijing 100021, Peoples R China

[3] Fuyang Peoples Hosp, Fu Yang City, An Hui Province, Peoples R China

[4] Univ Maryland, Med Ctr, Dept Med, Div Nephrol, Baltimore, MD 21201 USA

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2013年 / 35卷 / 01期

基金：

中国国家自然科学基金;

关键词：

aldosterone; angiotensin II; gastrin; hypertension; GENOME-WIDE ASSOCIATION; BLOOD-PRESSURE; RENAL-FUNCTION; CHOLECYSTOKININ; MECHANISMS; RECEPTORS; DOPAMINE; SODIUM; SALT; PENTAGASTRIN;

D O I：

10.3109/10641963.2012.690474

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Gastrin is a peptide hormone, which acts not only to regulate gastric acid secretion, but also to exert physiological actions such as the regulation of sodium balance. From a case (n = 95)-control (n = 82) study in Fuyang People's Hospital, Anhui Province, China, we found that the fasting serum gastrin levels are similar in normotensive and hypertensive adults but increased to higher levels in the latter group than in the former group after a mixed meal. We suggest that gastrin is involved in the regulation of blood pressure, possibly via the regulation of sodium and water metabolism and/or renin-angiotensin-aldosterone system. However, the mechanism remains to be determined.

引用

页码：74 / 78

页数：5

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