Expression of hepatocyte growth factor in primary sensory neurons of adult rats

被引：20

作者：

Hashimoto, N

Yamanaka, H

Fukuoka, T

Obata, K

Mashimo, T

Noguchi, K

机构：

[1] Hyogo Med Univ, Dept Anat & Neurosci, Nishinomiya, Hyogo 6638501, Japan

[2] Osaka Univ, Sch Med, Dept Anesthesiol & Acute Crit Med, Suita, Osaka 5650871, Japan

来源：

MOLECULAR BRAIN RESEARCH | 2001年 / 97卷 / 01期

关键词：

hepatocyte growth factor; cMet; dorsal root ganglion;

D O I：

10.1016/S0169-328X(01)00284-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the expression of hepatocyte growth factor (HGF) mRNA and its receptor, c-met mRNA, in the dorsal root ganglia (DRG) and spinal cord of naive adult rats using in situ hybridization histochemistry (ISHH) and the reverse transcription-polymerase chain reaction (RT-PCR) technique. HGF mRNA was expressed in 25.0% of DRG neurons and 80.5% of HGF mRNA-positive neurons expressed trk-A mRNA. In the lumbar spinal cord, c-met mRNA signals were observed in the superficial layer of dorsal horn. These results suggest that the HGF/cMet system may be involved in sensory transmission. (C) 2001 Elsevier Science B.V. All rights reserved.

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页码：83 / 88

页数：6

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