Expression of hepatocyte growth factor in primary sensory neurons of adult rats

被引:20
作者
Hashimoto, N
Yamanaka, H
Fukuoka, T
Obata, K
Mashimo, T
Noguchi, K
机构
[1] Hyogo Med Univ, Dept Anat & Neurosci, Nishinomiya, Hyogo 6638501, Japan
[2] Osaka Univ, Sch Med, Dept Anesthesiol & Acute Crit Med, Suita, Osaka 5650871, Japan
来源
MOLECULAR BRAIN RESEARCH | 2001年 / 97卷 / 01期
关键词
hepatocyte growth factor; cMet; dorsal root ganglion;
D O I
10.1016/S0169-328X(01)00284-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We examined the expression of hepatocyte growth factor (HGF) mRNA and its receptor, c-met mRNA, in the dorsal root ganglia (DRG) and spinal cord of naive adult rats using in situ hybridization histochemistry (ISHH) and the reverse transcription-polymerase chain reaction (RT-PCR) technique. HGF mRNA was expressed in 25.0% of DRG neurons and 80.5% of HGF mRNA-positive neurons expressed trk-A mRNA. In the lumbar spinal cord, c-met mRNA signals were observed in the superficial layer of dorsal horn. These results suggest that the HGF/cMet system may be involved in sensory transmission. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:83 / 88
页数:6
相关论文
共 18 条
[1]   IMMUNOCYTOCHEMICAL LOCALIZATION OF TRKA RECEPTORS IN CHEMICALLY IDENTIFIED SUBGROUPS OF ADULT-RAT SENSORY NEURONS [J].
AVERILL, S ;
MCMAHON, SB ;
CLARY, DO ;
REICHARDT, LF ;
PRIESTLEY, JV .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1995, 7 (07) :1484-1494
[2]   SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].
CHOMCZYNSKI, P ;
SACCHI, N .
ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) :156-159
[3]   HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR MODULATES INTESTINAL EPITHELIAL-CELL PROLIFERATION AND MIGRATION [J].
DIGNASS, AU ;
LYNCHDEVANEY, K ;
PODOLSKY, DK .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 202 (02) :701-709
[4]   Differential regulation of alpha- and beta-CGRP mRNAs within oculomotor, trochlear, abducens, and trigeminal motoneurons in response to axotomy [J].
Fukuoka, T ;
Tokunaga, A ;
Kondo, E ;
Miki, K ;
Tachibana, T ;
Noguchi, K .
MOLECULAR BRAIN RESEARCH, 1999, 63 (02) :304-315
[5]   Expression of HGF and cMet in the peripheral nervous system of adult rats following sciatic nerve injury [J].
Hashimoto, N ;
Yamanaka, H ;
Fukuoka, T ;
Dai, Y ;
Obata, K ;
Mashimo, T ;
Noguchi, K .
NEUROREPORT, 2001, 12 (07) :1403-1407
[6]   EXPRESSION AND FUNCTIONAL INTERACTION OF HEPATOCYTE GROWTH FACTOR-SCATTER FACTOR AND ITS RECEPTOR C-MET IN MAMMALIAN BRAIN [J].
JUNG, W ;
CASTREN, E ;
ODENTHAL, M ;
VANDEWOUDE, GF ;
ISHII, T ;
DIENES, HP ;
LINDHOLM, D ;
SCHIRMACHER, P .
JOURNAL OF CELL BIOLOGY, 1994, 126 (02) :485-494
[7]   TYROSINE PHOSPHORYLATION AND TYROSINE KINASE-ACTIVITY OF THE TRK PROTOONCOGENE PRODUCT INDUCED BY NGF [J].
KAPLAN, DR ;
MARTINZANCA, D ;
PARADA, LF .
NATURE, 1991, 350 (6314) :158-160
[8]   COEXPRESSION OF TRK FAMILY MEMBERS AND LOW-AFFINITY NEUROTROPHIN RECEPTORS IN RAT DORSAL-ROOT GANGLION NEURONS [J].
KASHIBA, H ;
NOGUCHI, K ;
UEDA, Y ;
SENBA, E .
MOLECULAR BRAIN RESEARCH, 1995, 30 (01) :158-164
[9]   THE TRK PROTOONCOGENE ENCODES A RECEPTOR FOR NERVE GROWTH-FACTOR [J].
KLEIN, R ;
JING, SQ ;
NANDURI, V ;
OROURKE, E ;
BARBACID, M .
CELL, 1991, 65 (01) :189-197
[10]  
KRASNOSELSKY A, 1994, J NEUROSCI, V14, P7284