Synthesis and structure-activity relationships of new non-steroidal progesterone receptor ligands

被引：20

作者：

Kurihara, K ^{[1
]}

Tanabe, K ^{[1
]}

Yamamoto, Y ^{[1
]}

Shinei, R ^{[1
]}

Ajito, K ^{[1
]}

Okonogi, T ^{[1
]}

机构：

[1] Meiji Seika Kaisha Ltd, Pharmaceut Res Ctr, Drug Discovery, Kohoku Ku, Yokohama, Kanagawa 2228567, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(99)00275-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In order to study structure-activity relationships, a series of new non-steroidal progesterone receptor ligands based on PF1092A (1)) was synthesized with structural modifications (mostly introduction or removal of a methyl group) at the 3-, 4-, 5-, 7- or 9-position in the 6-acetoxy-4a, 5, 6, 7-tetrahydro-3, 4a, 5-trimethylnaphtho[2, 3-b]furan-2(4H)-one (2)) skeleton. Critical positions for high binding affinity to the progesterone receptor were identified. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1837 / 1842

页数：6

共 15 条

[1] NEW METHOD FOR DEOXYGENATION OF SECONDARY ALCOHOLS [J].