MRI in multiple sclerosis during the menstrual cycle: Relationship with sex hormone patterns

被引：68

作者：

Pozzilli, C

Falaschi, P

Mainero, C

Martocchia, A

D'Urso, R

Proietti, A

Frontoni, M

Bastianello, S

Filippi, M

机构：

[1] Univ Roma La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Med Clin 1, I-00185 Rome, Italy

[3] Univ Milan, Sci Inst Osped S Raffaele, Dept Neurosci, Neuroimaging Res Unit, I-20122 Milan, Italy

来源：

NEUROLOGY | 1999年 / 53卷 / 03期

关键词：

D O I：

10.1212/WNL.53.3.622

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated MRI activity in MS during the menstrual cycle in relation to physiologic sex hormone fluctuations. Eight women with relapsing-remitting MS were submitted to serial brain gadolinium-enhanced MRI examinations over a 3-month period in two alternate follicular and luteal phases of the menstrual cycle. The ratio of progcsterone/17-beta-estradiol during the luteal phase was significantly associated with both number (r = 0.6, p = 0.03) and volume (r = 0.7, p = 0.009) of enhancing lesions, providing support for a role of these hormones as immunomodulatory factors in MS.

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收藏

页码：622 / 624

页数：3

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