Short day lengths attenuate the symptoms of infection in Siberian hamsters

被引:110
作者
Bilbo, SD
Drazen, DL
Quan, N
He, LL
Nelson, RJ
机构
[1] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA
[2] Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA
[3] Johns Hopkins Univ, Dept Psychol, Baltimore, MD 21218 USA
[4] Ohio State Univ, Dept Oral Biol, Columbus, OH 43210 USA
关键词
fever; anorexia; seasonality; sickness behaviour; immune function; adaptation;
D O I
10.1098/rspb.2001.1915
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Symptoms of infection, such as fever, anorexia and lethargy, are ubiquitous among vertebrates. Rather than nonspecific manifestations of illness, these responses are organized, adaptive strategies that are often critical to host survival. During times of energetic shortage such as winter, however, it may be detrimental for individuals to prolong energetically demanding symptoms such as fever. Individuals may adjust their immune responses prior to winter by using day length to anticipate energetically-demanding conditions. If the expression of sickness behaviours is constrained by energy availability, then cytokine production, fever, and anorexia should be attenuated in infected Siberian hamsters housed under simulated winter photoperiods. We housed hamsters in either long (14 L : 10 D) or short (10 L : 14 D) day lengths and assessed cytokines, anorexia and fever following injections of lipopolysaccharide (LPS). Short days attenuated the response to lipopolysaccharide, by decreasing the production of interleukin (IL)-6 and IL-1beta, and diminishing the duration of fever and anorexia. Short-day exposure in hamsters also decreased the ingestion of dietary iron, a nutrient vital to bacterial replication. Taken together, short day lengths attenuated the symptoms of infection, presumably to optimize energy expenditure and survival outcome.
引用
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页码:447 / 454
页数:8
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