Selenium status, sex hormones, and thyroid function in young women

The aim of the study was to identify those parameters characterising selenium status and sex hormones secretion, which are responsible for the changes in indicators of thyroid function, and to reveal the correlation structure of parameters expressing selenium status, sex hormones secretion and thyroid function, if any exist. The general approach in this work was essentially the same as in our previous report (cf. [Zagrodzki P, Ratajczak R, Wietecha-Posluszny R. The interaction between selenium Status, sex hormones, and thyroid metabolism in adolescent girls during the luteal phase of their menstrual cycle. Biol Trace Elem Res 2007. 120: 51-60]), but the Study group and parameters' spectrum were different. Thirty-six women aged 23.5+/-0.6 years were investigated. The parameters of interest were: plasma selenium concentration (Se) and plasma glutathione peroxidase activity (GPX3) (indicators of selenium status) serum estradiol (E2). progesterone (P4), follicle-stimulating hormone (TSH), luteotropic hormone (LH), and age of menarche (indicators of sex hormones secretion); thyroid-stirmulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3), anti-thyroid peroxidase antibodies in serum (anti-TPO), and thyroid volume (indicators of thyroid function). Our findings show that Se, GPX3, P4, LH, FSH, TSH and fT4 were interrelated. The pairs of parameters: GPX3 and P4; LH and FSH exhibited the strongest associations. The thyroid function parameters were mainly influenced by GPX3 and P4. Partial least-squares method corroborated our hypothesis about the existence of complex interactions among selenium status, sex hormones secretion, and thyroid function in healthy Young women in the luteal phase. (C) 2008 Elsevier GmbH. All rights reserved.