Cytotoxic activities of water-soluble chitosan derivatives with different degree of deacetylation

被引：54

作者：

Je, JY ^{[1
]}

Cho, YS ^{[1
]}

Kim, SK ^{[1
]}

机构：

[1] Pukyong Natl Univ, Dept Chem, Pusan 608737, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 08期

关键词：

water-soluble; chitosan derivatives; cytotoxic activity;

D O I：

10.1016/j.bmcl.2006.01.060

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Chitosans with different degree of deacetylation (DD) (90% and 50% deacetylated chitosan) were prepared by N-deacetylation followed by grafted onto chitosan to form water-soluble aminoethyl-chitosan (AE-chitosan), and dimetylaminoethyl-chitosan (DMAE-chitosan), diethylaminoethyl-chitosan (DEAE-chitosan). In the present study, cytotoxic activities of the chitosan derivatives were evaluated using three tumor cell lines and two normal cell lines, and structure-activity relationship was suggested. The cytotoxic activity was dependent on their DD and substituted group. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2122 / 2126

页数：5

共 16 条

[1]

FUNGICIDAL EFFECT OF CHITOSAN ON FUNGI OF VARYING CELL-WALL COMPOSITION [J].