Corticosteroids, the aging brain and cognition

被引：74

作者：

McEwen, BS

de Leon, MJ

Lupien, SJ

Meaney, MJ

机构：

[1] Rockefeller Univ, New York, NY 10021 USA

[2] NYU, Sch Med, Dept Psychiat, Neuroimaging Lab, New York, NY 10016 USA

[3] McGill Univ, Douglas Hosp, Res Ctr, Lab Psychoneuroendocrine Res, Verdun, PQ H4H 1R3, Canada

[4] Geriatr Inst Montreal, Lab Psychoneuorendocrine Res, Montreal, PQ H3W 1W5, Canada

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1999年 / 10卷 / 03期

关键词：

D O I：

10.1016/S1043-2760(98)00122-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The hippocampal region of the brain is a useful model system for understanding the plasticity and resilience of brain cells to stress hormone action and aging. Hippocampal neurons show both structural and functional plasticity, and individual differences in hippocampal function are shaped by early life experiences. For human brain aging, there are new non-invasive imaging fools to relate to the animal models, and these, can help to assess the vulnerability of the aging hippocampus in relation to stress and Alzheimer's disease.

引用

页码：92 / 96

页数：5

共 39 条

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