OPINION γH2AX and cancer

被引：1303

作者：

Bonner, William M. ^{[1
]}

Redon, Christophe E. ^{[1
]}

Dickey, Jennifer S. ^{[1
]}

Nakamura, Asako J. ^{[1
]}

Sedelnikova, Olga A. ^{[1
]}

Solier, Stephanie ^{[1
]}

Pommier, Yves ^{[1
]}

机构：

[1] NCI, Mol Pharmacol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS CANCER | 2008年 / 8卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc2523

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing gamma H2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may lead to cancer but, paradoxically, are also used to kill cancer cells. Using gamma H2AX detection to determine the extent of DSB induction may help to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs.

引用

页码：957 / 967

页数：11

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