Furanoid sugar amino acid based peptidomimetics: well-defined solution conformations to gel-like structures

被引：36

作者：

Chakraborty, TK ^{[1
]}

Jayaprakash, S ^{[1
]}

Srinivasu, P ^{[1
]}

Madhavendra, SS ^{[1
]}

Sankar, AR ^{[1
]}

Kunwar, AC ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Bioorgan Lab, Organ Div 3, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON | 2002年 / 58卷 / 14期

关键词：

peptide mimetics; hydrogen bonding; conformation; NMR; organogels;

D O I：

10.1016/S0040-4020(02)00158-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Furanoid sugar amino acid based peptide and a dimer fold into pseudo P-turn-like structures in DMSO-d(6) with intramolecular H-bonds between LeuNH and sugarOH. In CDCl3, they display a repeating beta-turn-type secondary structure at lower concentrations and start to form aggregates that gradually turn into excellent organogels as the concentrations are increased, a phenomenon observed for the first time in sugar amino acid containing peptides. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2853 / 2859

页数：7

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