Kidney Transplant Half-Life (t[1/2]) After Rapid Discontinuation of Prednisone

被引：13

作者：

Matas, Arthur J. ^{[1
]}

Gillingham, Kristen ^{[1
]}

Kandaswamy, Raja ^{[1
]}

Dunn, Ty B. ^{[1
]}

Payne, William D. ^{[1
]}

Sutherland, David E. R. ^{[1
]}

Humar, Abhinav ^{[1
]}

机构：

[1] Univ Minnesota, Dept Surg, Minneapolis, MN 55455 USA

来源：

TRANSPLANTATION | 2009年 / 87卷 / 01期

关键词：

Kidney transplantation; Prednisone; Immunosuppression; EARLY STEROID WITHDRAWAL; RENAL-TRANSPLANTATION; MYCOPHENOLATE-MOFETIL; FREE IMMUNOSUPPRESSION; CALCINEURIN INHIBITOR; DACLIZUMAB INDUCTION; DOUBLE-BLIND; CYCLOSPORINE; RECIPIENTS; METAANALYSIS;

D O I：

10.1097/TP.0b013e31818c25ab

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Protocols incorporating rapid discontinuation of prednisone (RI)P) after kidney transplantation have been associated with good short-term results. However, concern remains that RDP will be associated with decreased long-term graft Survival rates. We compared kidney transplant half-life (t(1/2)) for recipients treated with antibody induction, calcineurin inhibitor, antimetabolite, and RDP versus historical controls treated with antibody induction, calcineurin inhibitor, antimetabolite, and maintenance prednisone. For both living and deceased donor recipients, we found no difference between groups. We also found no differences in rate of graft loss to acute rejection or to tubular atrophy and interstitial fibrosis. Our study, suggests that long-term graft outcome is not decreased when using RDP protocols versus chronic maintenance prednisone.

引用

页码：100 / 102

页数：3

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