Pregabalin abuse among opiate addicted patients

被引:103
作者
Grosshans, Martin [1 ]
Lemenager, Tagrid [1 ]
Vollmert, Christian [1 ]
Kaemmerer, Nina [1 ]
Schreiner, Rupert [2 ]
Mutschler, Jochen [3 ]
Wagner, Xenija [1 ]
Kiefer, Falk [1 ]
Hermann, Derik [1 ]
机构
[1] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, D-68159 Mannheim, Germany
[2] Limbach Med Labs, Heidelberg, Germany
[3] Psychiat Univ Hosp Zurich, Dept Psychiat Psychotherapy & Psychosomat, Zurich, Switzerland
关键词
Pregabalin; Abuse; Opiate replacement therapy; Urine analysis; Mass spectrometry; ALCOHOL-WITHDRAWAL SYNDROME; HEALTHY-VOLUNTEERS; COMPARISON TRIAL; DEPENDENCE; DETOXIFICATION; COMBINATION; SEIZURES; BLIND; PAIN;
D O I
10.1007/s00228-013-1578-5
中图分类号
R9 [药学];
学科分类号
100702 [药剂学];
摘要
Pregabalin is a novel GABA-analogue approved for the treatment of partial onset seizures, neuropathic pain, and general anxiety disorder. Pregabalin has been classified as a Schedule V drug with a low risk of inflicting abuse or addiction. However, some publications have indicated that pregabalin may have a potential for abuse among patients with past or current opiate addiction. Thus, we hypothesized that pregabalin might be abused by patients who were undergoing an opiate replacement therapy and never had an indication for taking pregabalin on medical grounds. Urine specimens from 124 patients with opiate dependency syndrome and from 111 patients with other addiction disorders (alcohol, benzodiazepines, cannabis, amphetamines) were screened for pregabalin by means of a mass spectrometer analysis. We found 12.1 % of all urine specimens from patients with opiate addiction to be positive for pregabalin. None of the patients concerned had a medical indication for using pregabalin. In the control group, 2.7 % of the patients were tested positively for pregabalin, due to their taking it regularly for chronic pain or general anxiety. Our data suggest that pregabalin is liable to be abused among individuals with opiate dependency syndrome Thus, vigilance and caution are called for when patients with a past or current opiate dependency are exposed to treatment with pregabalin.
引用
收藏
页码:2021 / 2025
页数:5
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