Supramolecular Self-Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF-α siRNA against Systemic Inflammation

被引：90

作者：

Yin, Lichen ^{[1
]}

Song, Ziyuan ^{[1
]}

Qu, Qiuhao ^{[2
]}

Kim, Kyung Hoon ^{[1
]}

Zheng, Nan ^{[1
]}

Yao, Catherine ^{[1
]}

Chaudhury, Isthier ^{[1
]}

Tang, Haoyu ^{[1
]}

Gabrielson, Nathan P. ^{[2
]}

Uckun, Fatih M. ^{[3
]}

Cheng, Jianjun ^{[1
]}

机构：

[1] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA

[2] Univ Illinois, Inst Genom Biol, Urbana, IL 61801 USA

[3] Childrens Hosp Los Angeles, Childrens Ctr Canc & Blood Dis, Syst Immunobiol Lab, Div Hematol Oncol, Los Angeles, CA 90027 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 22期

基金：

美国国家科学基金会;

关键词：

inflammation; nanoparticles; siRNA; supramolecular self-assembly; TNF-alpha; CHITOSAN-DNA NANOPARTICLES; CROSS-LINKED NANOPARTICLES; NONVIRAL GENE DELIVERY; IN-VIVO DELIVERY; ANTIINFLAMMATORY TREATMENT; EFFICIENT DELIVERY; DRUG-DELIVERY; MACROPHAGES; EXPRESSION; MODEL;

D O I：

10.1002/anie.201209991

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A functional package: Multifunctional supramolecular self-assembled nanoparticles (SSNPs) consist of a set of rationally designed components that collectively facilitate efficient intestinal absorption of siRNA and induce potent TNF-α silencing in macrophages. Single gavage of SSNPs in mice depletes systemic TNF-α production at an siRNA dose as low as 50μg kg-1, and thus protects mice from lipopolysaccharide-induced hepatic injury. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5757 / 5761

页数：5

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