Molecularly imprinted polymers with strong carboxypeptidase A-like activity: Combination of an amidinium function with a zinc-ion binding site in transition-state imprinted cavities

Impressing models: A novel polymer catalyst shows even higher catalytic activity for the hydrolysis of carbonates than catalytic antibodies prepared for the same purpose. The catalyst was prepared by molecular imprinting with a stable transition state analogue and the introduction of an amidinium function and a Zn2+ ion in the active site in a defined orientation (see picture).