Interleukin 17: An example for gene therapy as a tool to study cytokine mediated regulation of hematopoiesis

被引:51
作者
Schwarzenberger, P [1 ]
Kolls, JK [1 ]
机构
[1] Louisiana State Univ, Hlth Sci Ctr New Orleans, Gene Therapy Program, New Orleans, LA 70112 USA
关键词
interleukin 17 (IL-17); gene therapy; hematopoiesis; T-cells; cytokines;
D O I
10.1002/jcb.10054
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Interleukin 17 (IL-17) is an essential proinflammatory T-cell derived cytokine with various biological actions. IL-17 was found to have a pivotal role in microbial host defense by interconnecting lymphoid and myeloid host defense. It also acts as a stimulatory hematopoietic cytokine by expanding myeloid progenitors and initiating proliferation of mature neutrophils. This article summarizes results to date on IL-17 research and discusses gene therapy based strategies that were employed to determine its biological functions and significance. A comprehensive working model for IL-17 is introduced.
引用
收藏
页码:88 / 95
页数:8
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