Polymorphisms in the prostate-specific antigen gene promoter do not predict serum prostate-specific antigen levels in African-American men

被引：10

作者：

Beebe-Dimmer, JL

Lange, LA

Cain, JE

Lewis, RC

Ray, AM

Sarma, AV

Lange, EM

Cooney, KA

机构：

[1] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Urol, Ann Arbor, MI USA

[3] Univ N Carolina, Dept Genet, Chapel Hill, NC USA

[4] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI USA

[5] Univ N Carolina, Dept Biostat, Chapel Hill, NC USA

来源：

PROSTATE CANCER AND PROSTATIC DISEASES | 2006年 / 9卷 / 01期

关键词：

prostate-specific antigen; single-nucleotide polymorphism; PSA gene;

D O I：

10.1038/sj.pcan.4500840

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A major problem with the use of serum prostate-specific antigen (PSA) in predicting prostate cancer risk is the considerable variability of such measurements. Cramer et al. identified a set of single-nucleotide polymorphisms ( SNPs) in the upstream regulatory region of the PSA gene that were each associated with increased promoter activity and serum PSA, further suggesting that genotyping these SNPs could be useful in improving the predictive value of PSA screening. In order to replicate this finding, DNA samples from 475 African-American men were genotyped for the same SNPs and no association was observed with either serum PSA level or prostate cancer diagnosis.

引用

收藏

页码：50 / 55

页数：6

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