Quorum sensing by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species

被引：222

作者：

Dubern, Jean-Frederic ^{[1
]}

Diggle, Stephen P. ^{[1
]}

机构：

[1] Univ Nottingham, Ctr Biomol Sci, Inst Infect Immun & Inflammat, Nottingham NG7 2RD, England

来源：

MOLECULAR BIOSYSTEMS | 2008年 / 4卷 / 09期

关键词：

D O I：

10.1039/b803796p

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pseudomonas aeruginosa produces the cell-to-cell signal molecule 2-heptyl-3-hydroxy-4-quinolone (The Pseudomonas quinolone signal; PQS), which is integrated within a complicated quorum sensing signaling system. PQS belongs to the family of 2-alkyl-4-quinolones (AQs), which have been previously described for their antimicrobial activities. PQS is synthesized via the pqsABCDE operon which is responsible for generating multiple AQs including 2-heptyl-4-quinolone (HHQ), the immediate PQS precursor. In addition, PQS signaling plays an important role in P. aeruginosa pathogenesis because it regulates the production of diverse virulence factors including elastase, pyocyanin and LecA lectin in addition to affecting biofilm formation. Here, we summarize the most recent findings on the biosynthesis and regulation of PQS and other AQs including the discovery of AQs in other bacterial species.

引用

页码：882 / 888

页数：7

共 45 条

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