Longitudinal changes of cortical thickness in early- versus late-onset Alzheimer's disease

被引：91

作者：

Cho, Hanna ^{[1
]}

Jeon, Seun ^{[2
]}

Kang, Sue J. ^{[1
]}

Lee, Jong-Min ^{[2
]}

Lee, Jae-Hong ^{[3
]}

Kim, Geon Ha ^{[1
]}

Shin, Ji Soo ^{[1
]}

Kim, Chi Hun ^{[1
]}

Noh, Young ^{[1
]}

Im, Kiho ^{[4
]}

Kim, Sung Tae ^{[5
]}

Chin, Juhee ^{[1
]}

Seo, Sang Won ^{[1
]}

Na, Duk L. ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul 135710, South Korea

[2] Hanyang Univ, Dept Biomed Engn, Seoul 133791, South Korea

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol, Seoul, South Korea

[4] Harvard Univ, Sch Med, Boston Childrens Hosp, Div Newborn Med, Boston, MA USA

[5] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiol, Seoul 135710, South Korea

来源：

NEUROBIOLOGY OF AGING | 2013年 / 34卷 / 07期

关键词：

Alzheimer's disease; Onset age; Early onset; Cortical thickness; Longitudinal study; APOE GENOTYPE; AGE; DEMENTIA; BRAIN; DISTURBANCES; PROGRESSION; SYMPTOMS; ATROPHY;

D O I：

10.1016/j.neurobiolaging.2013.01.004

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Early-onset Alzheimer's disease (EOAD) has been shown to progress more rapidly than late-onset Alzheimer's disease (LOAD). However, no studies have compared the topography of brain volume reduction over time. The purpose of this 3-year longitudinal study was to compare EOAD and LOAD in terms of their rates of decline in cognitive testing and topography of cortical thinning. We prospectively recruited 36 patients with AD (14 EOAD and 22 LOAD) and 14 normal controls. All subjects were assessed with neuropsychological tests and with magnetic resonance imaging at baseline, Year 1, and Year 3. The EOAD group showed more rapid decline than the LOAD group in attention, language, and frontal-executive tests. The EOAD group also showed more rapid cortical thinning in widespread association cortices. In contrast, the LOAD group presented more rapid cortical thinning than the EOAD group only in the left parahippocampal gyrus. Our study suggests that patients with EOAD show more rapid cortical atrophy than patients with LOAD, which accounts for faster cognitive decline on neuropsychological tests. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：1921.e9 / 1921.e15

页数：7

共 38 条

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