Ethical consideration of incidental findings on adult brain MRI in research

被引:93
作者
Illes, J
Rosen, AC
Huang, L
Goldstein, RA
Raffin, TA
Swan, G
Atlas, SW
机构
[1] Stanford Ctr Biomed Eth, Palo Alto, CA 94304 USA
[2] Stanford Univ, Dept Med, Palo Alto, CA 94304 USA
[3] Stanford Univ, Dept Radiol, Palo Alto, CA 94304 USA
[4] Stanford Univ, Dept Neurol & Neurol Sci, Palo Alto, CA 94304 USA
[5] Stanford Univ, Hoover Inst, Palo Alto, CA 94304 USA
[6] SRI Int, Menlo Pk, CA 94025 USA
关键词
D O I
10.1212/01.WNL.0000118531.90418.89
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To characterize the frequency and severity of incidental findings in brain MRIs of young and older adult research volunteers, and to provide an evaluation of the ethical challenges posed by the detection of such findings. Methods: The authors reviewed 151 research MRI scans obtained retrospectively from subjects recruited to studies as healthy volunteers. Incidental findings were classified into four categories: no referral, routine, urgent, or immediate referral. p Values for significance were computed from chi(2) tests of contingency. Results: Of 151 studies, the authors found an overall occurrence of incidental findings having required referral of 6.6%. By age, there were more findings in the older cohort (aged >60 years) than in the younger cohort (p<0.05) and in more men than women in the older cohort (p<0.001). Three of four (75%) findings in the younger cohort were classified in the urgent referral category; 100% of the findings in the older cohort were classified as routine (p<0.05). Conclusion: The significant presence but different characteristics of incidental findings in young and older subjects presumed to be neurologically healthy suggest that standards of practice are needed to guide investigators in managing and communicating their discovery.
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页码:888 / 890
页数:3
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