Effect of ischemic preconditioning and mitochondrial KATP channel openers on chronic left ventricular remodeling in the ischemic-reperfused rat heart

被引：21

作者：

Dairaku, Y ^{[1
]}

Miura, T ^{[1
]}

Harada, N ^{[1
]}

Kimura, M ^{[1
]}

Okamura, T ^{[1
]}

Iwamoto, H ^{[1
]}

Kametani, R ^{[1
]}

Yamada, M ^{[1
]}

Ikeda, Y ^{[1
]}

Iwatate, M ^{[1
]}

Kawamura, S ^{[1
]}

Matsuzaki, M ^{[1
]}

机构：

[1] Yamaguchi Univ, Sch Med, Div Cardiovasc Med, Dept Cardiovasc Med Med Bioregulat, Ube, Yamaguchi 7558505, Japan

来源：

CIRCULATION JOURNAL | 2002年 / 66卷 / 04期

关键词：

diazoxide; ischemic preconditioning; nicorandil; pressure-volume curve;

D O I：

10.1253/circj.66.411

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The influence of ischemic preconditioning (IP) and mitochondrial ATP-sensitive potassium (rrdto-KATP) channel openers on chronic left ventricular (LV) remodeling remains unknown, so the effect of IP and mito-KATP channel openers on the LV pressure-volume curve was assessed in rats subjected to 30 min ischemia followed by a 3-week reperfusion. Infarct size was histologically determined at 3 weeks after reperfusion. The LV pressure-volume curve was significantly shifted left by IP, diazoxide and nicorandil compared with the controls. These effects were blocked by the selective mito-KATP channel blocker 5-hydroxydecanoate. The LV remodeling and the infarct size at 3 weeks after reperfusion correlated well, indicating that the reduction of LV remodeling in the ischemic-reperfused model was strongly influenced by attenuation of the ischemic injury. LV remodeling in the chronic phase is attenuated by IP and mito-KATP channel openers with concomitant reduction of infarct size.

引用

页码：411 / 415

页数：5

共 42 条

[1] BLOCKADE OF ISCHEMIC PRECONDITIONING IN DOGS BY THE NOVEL ATP DEPENDENT POTASSIUM CHANNEL ANTAGONIST SODIUM 5-HYDROXYDECANOATE [J].

AUCHAMPACH, JA ;

GROVER, GJ ;

GROSS, GJ .

CARDIOVASCULAR RESEARCH, 1992, 26 (11) :1054-1062

[2] Preconditioning in immature rabbit hearts role of KATP channels [J].

Baker, JE ;

Holman, P ;

Gross, GJ .

CIRCULATION, 1999, 99 (09) :1249-1254

[3] RELATION OF INITIAL INFARCT SIZE TO EXTENT OF LEFT-VENTRICULAR REMODELING IN THE YEAR AFTER ACUTE MYOCARDIAL-INFARCTION [J].

CHAREONTHAITAWEE, P ;

CHRISTIAN, TF ;

HIROSE, K ;

GIBBONS, RJ ;

RUMBERGER, JA .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1995, 25 (03) :567-573

[4] Smaller infarct after preconditioning does not predict extent of early functional improvement of reperfused heart [J].

Cohen, MV ;

Yang, XM ;

Downey, JM .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1999, 277 (05) :H1754-H1761

[5]

Cohen MV, 2000, CIRCULATION, V102, P579

[6] Potassium channel activation and relaxation by nicorandil in rat small mesenteric arteries [J].

Davie, CS ;

Kubo, M ;

Standen, NB .

BRITISH JOURNAL OF PHARMACOLOGY, 1998, 125 (08) :1715-1725

[7] EARLY PHASE ACUTE MYOCARDIAL INFARCT SIZE QUANTIFICATION - VALIDATION OF THE TRIPHENYL TETRAZOLIUM CHLORIDE TISSUE ENZYME STAINING TECHNIQUE [J].

FISHBEIN, MC ;

MEERBAUM, S ;

RIT, J ;

LANDO, U ;

KANMATSUSE, K ;

MERCIER, JC ;

CORDAY, E ;

GANZ, W .

AMERICAN HEART JOURNAL, 1981, 101 (05) :593-600

[8] Ischemic preconditioning in rats:: role of mitochondrial KATP channel in preservation of mitochondrial function [J].

Fryer, RM ;

Eells, JT ;

Hsu, AK ;

Henry, MM ;

Gross, GJ .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2000, 278 (01) :H305-H312

[9]

Garlid KD, 1997, CIRC RES, V81, P1072

[10] The mitochondrial K-ATP channel as a receptor for potassium channel openers [J].

Garlid, KD ;

Paucek, P ;

YarovYarovoy, V ;

Sun, XC ;

Schindler, PA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (15) :8796-8799

← 1 2 3 4 5 →