Biocompatible Hydrogels in Spinal Cord Injury Repair

被引：86

作者：

Hejcl, A. ^{[1
,2
,4
]}

Lesny, P. ^{[1
,2
]}

Pradny, M. ^{[2
,3
]}

Michalek, J. ^{[2
,3
]}

Jendelova, P. ^{[1
,2
]}

Stulik, J. ^{[5
]}

Sykova, E. ^{[1
,2
]}

机构：

[1] Acad Sci Czech Republ, Inst Expt Med, Videnska 1083, Prague 14220 4, Czech Republic

[2] Charles Univ Prague, Ctr Cell Therapy & Tissue Repair, Fac Med 2, Prague, Czech Republic

[3] Acad Sci Czech Republ, Inst Macromol Chem, Prague 14220 4, Czech Republic

[4] Masaryk Hosp, Dept Neurosurg, Usti Nad Labem, Czech Republic

[5] Univ Hosp Motol, Dept Spondylosurg, Prague, Czech Republic

来源：

PHYSIOLOGICAL RESEARCH | 2008年 / 57卷

关键词：

Spinal cord injury; Hydrogel; Tissue engineering; Stem cells; Regenerative medicine;

D O I：

10.33549/physiolres.931606

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Spinal cord injury results in a permanent neurological deficit due to tissue damage. Such a lesion is a barrier for "communication" between the brain and peripheral tissues, effectors as well as receptors. One of the primary goals of tissue engineering is to bridge the spinal cord injury and re-establish the damaged connections. Hydrogels are biocompatible implants used in spinal cord injury repair. They can create a permissive environment and bridge the lesion cavities by providing a scaffold for the regeneration of neurons and their axons, glia and other tissue elements. The advantage of using artificial materials is the possibility to modify their physical and chemical properties in order to develop the best implant suitable for spinal cord injury repair. As a result, several types of hydrogels have been tested in experimental studies so far. We review our work that has been clone during the last 5 years with various types of hydrogels and their applications in experimental spinal cord injury repair.

引用

页码：S121 / S132

页数：12

共 69 条

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Mechanically engineered hydrogel scaffolds for axonal growth and angiogenesis after transplantation in spinal cord injury [J].