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Molecularly imprinted polymers for the enantioseparation of chiral drugs

被引：125
作者：
Ansell, RJ [1 ]
机构：
[1] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2005年 / 57卷 / 12期
关键词：
enantiomers; chiral stationary phase (CSP); high performance liquid chromatography (HPLC); thin layer chromatography (TLC); supercritical fluid chromatography (SFC); capillary electrochromatography (CEC);
D O I：
10.1016/j.addr.2005.07.014
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Molecularly imprinted polymers have been applied for many years in chiral separations and increasingly have been applied to drugs. Separation speed and efficiency in methods such as HPLC and CEC are increasingly competitive with alternative established CSPs. The literature on separation Of drug enantiomers using MIN via HPLC, TLC, SFC and CEC are reviewed. Issues for method development, particularly the monomer template interactions during the imprinting process, and the mechanism of solute retention on MIP CSPs in chromatography using normal phase or reverse-phase mobile phases are considered. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：1809 / 1835
页数：27
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