Viral persistence: Parameters, mechanisms and future predictions

被引：73

作者：

Oldstone, MBA

机构：

[1] Scripps Res Inst, Mol & Integrat Neurosci Dept, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Infectol, La Jolla, CA 92037 USA

来源：

VIROLOGY | 2006年 / 344卷 / 01期

关键词：

persistent infection; T cell function; dendritic cell function; immune clearance; differentiated function;

D O I：

10.1016/j.virol.2005.09.028

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

For a virus to persist, it must actively curtail the host's antiviral immune response. Here, we review the conceptual basis by which this can occur and discuss the subsequent fate of differentiated cells infected over long periods of time. We also consider how the compromised antiviral immune response can be revigorated or replaced with a potent response that purges the virus and thereby terminates persistent infection. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：111 / 118

页数：8

共 44 条

[1] VIRUS-LYMPHOCYTE INTERACTION - T-CELLS OF THE HELPER SUBSET ARE INFECTED WITH LYMPHOCYTIC CHORIOMENINGITIS VIRUS DURING PERSISTENT INFECTION INVIVO [J].