Cofilin phosphatases and regulation of actin dynamics

被引：266

作者：

Huang, TY

DerMardirossian, C

Bokoch, GM

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2006年 / 18卷 / 01期

关键词：

D O I：

10.1016/j.ceb.2005.11.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cofilin is a ubiquitous actin-binding factor required for the reorganization of actin filaments in eukaryotes. The dephosphorylation of cofilin enables its actin severing and depolymerizing activity and drives directional cell motility, thus providing a simple phosphoregulatory mechanism for actin reorganization. To date, two cofilin-specific phosphatases have been identified: Slingshot and Chronophin. These cofilin phosphatases are unrelated in sequence and regulatory properties, each potentially providing a unique mechanism for cofilin activation under varying biological circumstances.

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页码：26 / 31

页数：6

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