Immune-Related Adverse Effects of Cancer Immunotherapy - Implications for Rheumatology

被引：93

作者：

Cappelli, Laura C. ^{[1
]}

Shah, Ami A. ^{[1
]}

Bingham, Clifton O., III ^{[1
]}

机构：

[1] Johns Hopkins Sch Med, Div Rheumatol, 5501 Hopkins Bayview Circle,Suite 1-B1, Baltimore, MD USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2017年 / 43卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Arthritis; Sicca syndrome; Immune checkpoint inhibitors; Malignancy; Immune-related adverse events; IPILIMUMAB; NIVOLUMAB; PEMBROLIZUMAB; TOXICITIES; BLOCKADE; MELANOMA; PATIENT; MANAGEMENT; PD-1; AUTOIMMUNITY;

D O I：

10.1016/j.rdc.2016.09.007

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Immune checkpoint inhibitors (ICIs) are increasingly studied and used as therapy for a growing number of malignancies. las work by blocking inhibitory pathways of T-cell activation, leading to an immune response directed against tumors. Such nonspecific immunologic activation can lead to immune-related adverse events (IRAEs). Some IRAEs, including inflammatory arthritis, sicca syndrome, myositis, and vasculitis, are of special interest to rheumatologists. As use of las increases, recognition of these IRAEs and developing treatment strategies will become important. In this review, the current literature on rheumatic and musculoskeletal IRAEs is summarized. The incidence, clinical presentations, and treatment considerations are highlighted.

引用

页码：65 / +

页数：15

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