Effect of age and ovariectomy on fibroblastic colony-forming unit numbers in rat bone marrow

被引：13

作者：

Scutt, A ^{[1
]}

Kollenkirchen, U ^{[1
]}

Bertram, P ^{[1
]}

机构：

[1] SCHERING RES LABS,D-13353 BERLIN,GERMANY

来源：

CALCIFIED TISSUE INTERNATIONAL | 1996年 / 59卷 / 04期

关键词：

D O I：

10.1007/s002239900130

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is now thought that osteoblasts (OB) stem from mesenchymal precursor cells (fibroblastic colony forming units or CFU-f) in the bone marrow. As the availability of these cells may have a profound effect on bone formation, the effect of age and ovariectomy (OVX) on CFU-f numbers was studied. It was found that with increasing age the numbers of CFU-f in the marrow were drastically reduced. OVX had no effect on CFU-flevels in 4 week and 4 month old rats but raised CFU-f levels in 1 year old rats back to levels seen in younger rats. Sham operation alone had an effect on CFU-f levels in older rats and the OVX effects were indistiguishable from the sham effect until 20 d post operation when the sham levels returned to baseline. The results show that CFU-flevels follow a similar trend to the rates of bone formation seen in aged and OVX rats.

引用

页码：309 / 310

页数：2

共 12 条

[1] THE NUMBER OF FIBROBLASTIC COLONIES FORMED FROM BONE-MARROW IS DECREASED AND THE INVITRO PROLIFERATION RATE OF TRABECULAR BONE-CELLS INCREASED IN AGED RATS [J].