Calcium-sensing receptor regulation of renal mineral ion transport

被引：57

作者：

Ba, JM

Friedman, PA

机构：

[1] Univ Pittsburgh, Sch Med, Dept Pharmacol, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15261 USA

来源：

CELL CALCIUM | 2004年 / 35卷 / 03期

关键词：

calcium-sensing receptor (CaSR); parathyroid hormone (PTH); Ca transport; Pi transport;

D O I：

10.1016/j.ceca.2003.10.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Extracellular calcium has long been known to affect the rate and magnitude of renal calcium and phosphate recovery. In this review, we consider some of these findings in light of our present understanding of the tubular localization of the calcium-sensing receptor (CaSR). Experiments directly implicating the CaSR in regulating calcium and phosphate transport are described. These results point to an important role of the CaSR in regulating PTH-dependent calcium absorption by cortical thick ascending limbs and on PTH-sensitive proximal tubule phosphate transport. Possible avenues for further investigation are suggested. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：229 / 237

页数：9

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