Interferon-producing cells: on the front line in immune responses against pathogens

被引：193

作者：

Colonna, M ^{[1
]}

Krug, A ^{[1
]}

Cella, M ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(02)00349-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interferon-producing cells (IPC) constitute a small population of leukocytes that secrete high levels of type I interferons in response to viruses. Although human I PC have been known for almost two decades, murine IPC have been identified only recently. Furthermore, it has been shown that IPC correspond to the enigmatic 'plasmacytoid cells' identified in human lymph nodes during infections. These breakthroughs have brought IPC to the attention of immunologists for their role in innate immunity and in shaping T cell responses. Here we review recent progress and outstanding questions in the field.

引用

页码：373 / 379

页数：7

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