In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum β-lactamase

被引：114

作者：

Elliott, E

Brink, AJ

van Greune, J

Els, Z

Woodford, N

Turton, J

Warner, M

Livermore, DM

机构：

[1] Milpark Hosp, Ampath Labs, Dept Clin Microbiol, Johannesburg, South Africa

[2] N1 City Hosp, Ampath Labs, Dept Clin Microbiol, Cape Town, South Africa

[3] Hlth Protect Agcy Colindale, Antiobiot Resistance Monitoring & Reference Lab, Ctr Infect, London, England

[4] Hlth Protect Agcy Colindale, Lab Healthcare Associated Infect, Ctr Infect, London, England

来源：

CLINICAL INFECTIOUS DISEASES | 2006年 / 42卷 / 11期

关键词：

D O I：

10.1086/503264

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Four sequential extended-spectrum beta-lactamase-producing isolates of Klebsiella pneumoniae were obtained from a patient after treatment with ertapenem and cultured. The first and fourth isolates were susceptible to ertapenem, whereas the second and third were resistant. All 4 isolates belonged to the same strain and produced a group 1 CTX-M enzyme; additionally, the resistant isolates had lost a porin.

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页码：E95 / E98

页数：4

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