Combinatorial chemistry of piperidine based carbohydrate mimics.

被引：23

作者：

Byrgesen, E

Nielsen, J

Willert, M

Bols, M

机构：

[1] TECH UNIV DENMARK,DEPT ORGAN CHEM,DK-2800 LYNGBY,DENMARK

[2] AARHUS UNIV,DEPT CHEM,DK-8000 AARHUS,DENMARK

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(97)01249-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Piperidine carboxylic acids and 4-hydroxypiperidine-3-carboxylic acid, the latter obtained from bakers yeast reduction of the corresponding piperidone, were coupled in solid-phase synthesis to form simplified oligosaccharide analogues. A split-and-mix synthesis approach was used to create small combinatorial libraries which were characterised by LC-MS and screened as inhibitors of glycosidases. (C) 1997 Elsevier Science Ltd.

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页码：5697 / 5700

页数：4

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