Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors

被引：18

作者：

Choi, C ^{[1
]}

Li, JH ^{[1
]}

Vaal, M ^{[1
]}

Thomas, C ^{[1
]}

Limburg, D ^{[1
]}

Wu, YQ ^{[1
]}

Chen, Y ^{[1
]}

Soni, R ^{[1
]}

Scott, C ^{[1
]}

Ross, DT ^{[1
]}

Guo, H ^{[1
]}

Howorth, P ^{[1
]}

Valentine, H ^{[1
]}

Liang, S ^{[1
]}

Spicer, D ^{[1
]}

Fuller, M ^{[1
]}

Steiner, J ^{[1
]}

Hamilton, GS ^{[1
]}

机构：

[1] Guilford Pharmaceut Inc, Res Dept, Baltimore, MD 21224 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(02)00147-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using simple, inexpensive equipment, we have used solution-phase parallel synthesis to rapidly prepare hundreds of sulfonamide- and urea-containing FKBP inhibitors, resulting in rapid identification of extremely potent compounds in these series. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1421 / 1428

页数：8

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