Subconjunctival bevacizumab for corneal neovascularization

被引:65
作者
Doctor, Priyanka P. [1 ]
Bhat, Pooja V. [1 ]
Foster, C. Stephen [1 ]
机构
[1] Harvard Univ, Sch Med, Massachusetts Eye Res & Surg Inst, Ocular Immunol & Uveitis Fdn, Cambridge, MA 02142 USA
关键词
subconjunctival bevacizumab; avastin; corneal neovascularization;
D O I
10.1097/ICO.0b013e31817786ad
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To describe whether subconjunctival bevacizumab decreases corneal in patients with ocular surface inflammatory diseases. Methods: The study is a retrospective case series that includes 8 eyes of 7 patients with corneal neovascularization. Patients received 1-3 injections of 2.5 mg subconjunctival bevacizumab. changes, were assessed clinically by the same investigator at each visit. Results: Subconjunctival bevacizumab was well-tolerated without obvious, corneal side effects. All 8 eyes of the 7 patients showed a recduction in the neovascularized area. Conclusions: Subconjunctival bevacizumab may provide an additional strategy in improving vision or improving success of corneal grafts in these patients.
引用
收藏
页码:992 / 995
页数:4
相关论文
共 24 条
[1]  
Amano S, 1998, INVEST OPHTH VIS SCI, V39, P18
[2]   Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration [J].
Avery, RL ;
Pieramici, DJ ;
Rabena, MD ;
Castellarin, AA ;
Nasir, MA ;
Giust, MJ .
OPHTHALMOLOGY, 2006, 113 (03) :363-372
[3]   Intravitreal bevacizumab (Avastin) in the treatment of proliferative diabetic retinopathy [J].
Avery, Robert L. ;
Pearlman, Joel ;
Pieramici, Dante J. ;
Rabena, Melvin D. ;
Castellarin, Alessandro A. ;
Nasir, Ma'an A. ;
Giust, Matthew J. ;
Wendel, Robert ;
Patel, Arun .
OPHTHALMOLOGY, 2006, 113 (10) :1695-1705
[4]   Intravitreal bevacizumab for the management of choroidal neovascularization in age-related macular degeneration [J].
Bashshur, Ziad F. ;
Bazarbachi, Ali ;
Schakal, Alexandre ;
Haddad, Zeina A. ;
El Haibi, Christelle P. ;
Noureddin, Baha' N. .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2006, 142 (01) :1-9
[5]   The heparan sulfate suleparoide inhibits rat corneal angiogenesis and in vitro neovascularization [J].
Benelli, U ;
Bocci, G ;
Danesi, R ;
Lepri, A ;
Bernardini, N ;
Bianchi, F ;
Lupetti, M ;
Dolfi, A ;
Campagni, A ;
Agen, C ;
Nardi, M ;
Del Tacca, M .
EXPERIMENTAL EYE RESEARCH, 1998, 67 (02) :133-142
[6]   Corneal neovascularization [J].
Chang, Jin-Hong ;
Gabison, Eric E. ;
Kato, Takuji ;
Azar, Dimitri T. .
CURRENT OPINION IN OPHTHALMOLOGY, 2001, 12 (04) :242-249
[7]   A NEW CLASS OF STEROIDS INHIBITS ANGIOGENESIS IN THE PRESENCE OF HEPARIN OR A HEPARIN FRAGMENT [J].
CRUM, R ;
SZABO, S ;
FOLKMAN, J .
SCIENCE, 1985, 230 (4732) :1375-1378
[8]   Immunohistochemical localization of vascular endothelial growth factor, transforming growth factor α, and transforming growth factor β1 in human corneas with neovascularization [J].
Cursiefen, C ;
Rummelt, C ;
Küchle, M .
CORNEA, 2000, 19 (04) :526-533
[9]   THALIDOMIDE IS AN INHIBITOR OF ANGIOGENESIS [J].
DAMATO, RJ ;
LOUGHNAN, MS ;
FLYNN, E ;
FOLKMAN, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :4082-4085
[10]   Topical bevacizumab therapy for corneal neovascularization [J].
DeStafeno, John J. ;
Kim, Terry .
ARCHIVES OF OPHTHALMOLOGY, 2007, 125 (06) :834-836