IgE, mast cells, basophils, and eosinophils

被引：271

作者：

Prussin, C ^{[1
]}

Metcalfe, DD ^{[1
]}

机构：

[1] NIAID, LAD, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2006年 / 117卷 / 02期

关键词：

IgE; IgE receptor; mast cell; basophil; eosinophil;

D O I：

10.1016/j.jaci.2005.11.016

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

IgE, mast cells, basophils, and eosinophils constitute essential elements in allergic inflammation. Allergen-specific IgE, synthesized in response to allergens in the environment, becomes fixed to Fc epsilon RI on the membranes of mast cells and basophils. Aggregation of receptor-bound IgE molecules on re-exposure to specific allergen results in the production of mediators that produce the allergic response. Principal among the cells drawn to sites of mediator release is the eosinophil.

引用

收藏

页码：S450 / S456

页数：7

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