Life is a journey: A genetic look at neocortical development

被引：294

作者：

Gupta, A

Tsai, LH

Wynshaw-Boris, A

机构：

[1] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Pathol, Boston, MA 02115 USA

[2] Univ Calif San Diego, Sch Med, Dept Pediat, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS GENETICS | 2002年 / 3卷 / 05期

关键词：

D O I：

10.1038/nrg799

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Although the basic principles of neocortical development have been known for quite some time, it is only recently that our understanding of the molecular mechanisms that are involved has improved. Such understanding has been facilitated by genetic approaches that have identified key proteins involved in neocortical development, which have been placed into signalling pathways by molecular and cell-biological studies. The challenge of current research is to understand the manner in which these various signalling pathways are interconnected to gain a more comprehensive picture of the molecular intricacies that govern neocortical development.

引用

收藏

页码：342 / 355

页数：14

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