Biogenesis of small RNAs in animals

被引：2513

作者：

Kim, V. Narry ^{[1
,2
]}

Han, Jinju ^{[1
,2
]}

Siomi, Mikiko C. ^{[3
,4
]}

机构：

[1] Seoul Natl Univ, Sch Biol Sci, Seoul 151742, South Korea

[2] Seoul Natl Univ, Ctr Natl Creat Res, Seoul 151742, South Korea

[3] Keio Univ, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan

[4] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3320012, Japan

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 02期

基金：

日本科学技术振兴机构;

关键词：

PIWI-INTERACTING RNAS; SELFISH GENETIC ELEMENTS; MEDIATES NUCLEAR EXPORT; POSTTRANSCRIPTIONAL REGULATION; DROSOPHILA-MELANOGASTER; MICRORNA MATURATION; ENDOGENOUS SIRNAS; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; BINDING PROTEIN;

D O I：

10.1038/nrm2632

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Small RNAs of 20-30 nucleotides can target both chromatin and transcripts, and thereby keep both the genome and the transcriptome under extensive surveillance. Recent progress in high-throughput sequencing has uncovered an astounding landscape of small RNAs in eukaryotic cells. Various small RNAs of distinctive characteristics have been found and can be classified into three classes based on their biogenesis mechanism and the type of Argonaute protein that they are associated with: microRNAs (miRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs) and Piwi-interacting RNAs (piRNAs). This Review summarizes our current knowledge of how these intriguing molecules are generated in animal cells.

引用

页码：126 / 139

页数：14

共 198 条

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