Urease-based mucosal immunization against Helicobacter heilmannii infection induces corpus atrophy in mice

被引:18
作者
Dieterich, C
Bouzourène, H
Blum, AL
Corthésy-Theulaz, IE
机构
[1] CHU Vaudois, Dept Internal Med, Div Gastroenterol, CH-1011 Lausanne, Switzerland
[2] Univ Lausanne, Inst Pathol, Lausanne, Switzerland
关键词
D O I
10.1128/IAI.67.11.6206-6209.1999
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Mucosal immunization with Helicobacter heilmannii urease B or Helicobacter pylori urease, given nasally with cholera toxin, protects BALB/c mice against H. heilmannii infection and significantly reduces a preexisting infection. However, immunization aggravates gastric corpus atrophy. Our results underline the necessity of defining immunization regimens that do not enhance mucosal damage.
引用
收藏
页码:6206 / 6209
页数:4
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