Tuberculosis: a balanced diet of lipids and carbohydrates

被引：11

作者：

Bhowruth, Veemal ^{[1
]}

Alderwick, Luke J. ^{[1
]}

Brown, Alistair K. ^{[1
]}

Bhatt, Apoorva ^{[1
]}

Besra, Gurdyal S. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

arabinogalactan; biosynthesis; cell wall; drug target; Mycobacterium tuberculosis; mycolic acid;

D O I：

10.1042/BST0360555

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In spite of effective antibiotics to treat TB (tuberculosis) since the early 1960s, we enter the new millennium with TB currently the leading cause of death from a single infectious agent, killing more than 3 million people worldwide each year. Thus an understanding of drug-resistance mechanisms, the immunobiology of cell wall components to elucidate host-pathogen interactions and the discovery of new drug targets are now required for the treatment of TB. Above the plasma membrane is a classical chemotype IV pepticloglycan to which is attached the macromolecular structure, mycolyl-arabinogalactan via a unique diglycosylphosphoryl bridge. The present review discusses the assembly of the mAGP (mycolyl-arabinogalactan-peptidoglycan) complex and the site of action of EMB (ethambutol), bringing forward a new era in TB research and focus for new drugs to combat multidrug-resistant TB.

引用

页码：555 / 565

页数：11

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